GHK-Cu is a copper-binding tripeptide that functions as a signal molecule regulating wound healing, tissue remodeling, and cellular regeneration. By chelating copper ions, it activates metalloproteinases (MMP-2 and MMP-9) and stimulates fibroblast proliferation, collagen I & III synthesis, glycosaminoglycan production, and stimulate hair follicle vitality.
Peptide Type: Signal and carrier peptide
Cat Number: PLS-SIG-003
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PRODUCT INFORMATION |
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I. TECHNICAL SPECIFICATIONS |
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Structural / Composition Data |
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Structure / Formula |
Gly–His–Lys·Cu²⁺ |
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Molecular Weight |
403.93 Da |
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Appearance |
Blue powder |
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Purity |
≥ 99% (HPLC) |
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Solubility |
Soluble in water and PBS buffer |
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Form(s) Available |
Lyophilized powder / solution (Conc. 0.1-10%) |
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Stability & Shelf Life |
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Storage |
Store at -20°C (for 24 month), at 2–8°C (for 12 month), protected from light |
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Post-Reconstitution |
Stable for 7–10 days at 2–8°C |
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Stability Notes |
Stable for 24 months under recommended storage conditions |
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Quality & Compliance |
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QC Tests |
HPLC purity, Mass spectrometry, ICP-MS for Cu confirmation |
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Intended Use |
Research, cosmetic formulation, and peptide complex formulation |
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Documentation |
Certificate of Analysis (CoA), Safety Data Sheet (SDS), Specification Sheet |
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II. PREPARATION / RECONSTITUTION |
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General Guidance |
Reconstitute in sterile water or PBS to desired concentration. Mix gently without vortexing. |
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Recommendations |
Avoid repeated freeze-thaw cycles. Filter sterilize before cell culture use |
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III. MECHANISM & BIOLOGICAL FUNCTION |
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Mechanism of Action |
GHK-Cu binds copper ions and promotes enzymatic activation of matrix remodeling, stimulating fibroblast proliferation and collagen synthesis. Enhances antioxidant enzyme activity and reduces oxidative stress. |
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Biological Claims |
Increases collagen I & III synthesis, enhances wound healing, improves hair follicle growth, reduces inflammation, and tightens skin matrix. |
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IV. APPLICATIONS |
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Intended Uses |
Skin rejuvenation, wound healing, hair growth stimulation, |
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V. PACKAGING & PRESENTATION |
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Sizes |
50 mg |
100 mg |
500 mg |
1 g |
Small molecule (Gly–His–Lys) forming a tight copper chelate; high redox potential and wound-healing capacity
Copper ion chelation complex
Tripeptide GHK molecular sequence
High-purity peptide (≥98%)
Lyophilized powder for stability
Pharmaceutical-grade formulation
Biocompatible carrier base
GHK-Cu the link between biotechnology and advanced skincare science.
It repairs, protects, and rejuvenates at the molecular level
Representing the future of peptide-based dermal renewal.
Unlike standard peptides, GHK-Cu actively binds copper ions, triggering enzymatic processes that stimulate collagen and tissue repair.
Yes. It pairs well with most actives but should be applied in separate formulations to maintain peptide integrity.
Ideal for serums, ampoules, post-procedure treatments, and anti-aging creams.
Recommended Dosage: 0.1 – 1.0% (topical peptide eq.)
Next-Generation Life Science Products for Everyday Health.