A neuropeptide complex that works by modulating neuromuscular activity to visibly reduce facial expression lines. Acetyl Hexapeptide-8 mimics the SNAP-25 N-terminal domain, preventing SNARE complex formation and thereby reducing acetylcholine release. This results in smoother skin and a relaxed facial appearance without the need for injections.
Peptide Type: Neurotransmission-modulating peptide
Cat Number: PLS-BIO-002
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PRODUCT INFORMATION |
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I. TECHNICAL SPECIFICATIONS |
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Structural / Composition Data |
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Structure / Formula |
Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂ |
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Molecular Weight |
~889.0 Da |
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Appearance |
White to off-white lyophilized powder |
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Purity |
≥ 99% (HPLC) |
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Solubility |
Soluble in water and ethanol (1:1) |
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Form(s) Available |
Lyophilized powder / aqueous solution |
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Stability & Shelf Life |
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Storage |
Store at -20°C, protected from light |
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Post-Reconstitution |
Stable for 7 days at 2–8°C |
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Stability Notes |
Stable for up to 24 months under recommended storage conditions |
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Quality & Compliance |
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QC Tests |
HPLC purity, Mass spectrometry (ESI-MS), peptide sequencing |
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Intended Use |
Cosmetic ingredient, anti-wrinkle formulations, topical peptide systems |
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Documentation |
CoA, SDS, Specification Sheet, Technical Data Sheet |
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II. PREPARATION / RECONSTITUTION |
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General Guidance |
Reconstitute with 1 mL sterile distilled water or buffer (pH 6–7), to obtain 100 mg/mL concentration. Gently mix until fully dissolved. |
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Recommendations |
Avoid vigorous shaking and multiple freeze–thaw cycles. Add directly to the aqueous phase of formulations. |
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III. MECHANISM & BIOLOGICAL FUNCTION |
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Mechanism of Action |
Acetyl Hexapeptide-8 mimics the N-terminal domain of SNAP-25, competing with natural SNAP-25 for SNARE complex formation. This reduces neurotransmitter release at neuromuscular junctions, decreasing muscle contraction and expression wrinkles. |
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Biological Claims |
Reduces the depth of facial wrinkles, especially in the forehead and eye areas; provides a Botox-like smoothing effect without muscle paralysis. |
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IV. APPLICATIONS |
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Intended Uses |
Anti-aging serums, wrinkle-reducing creams, eye contour formulations, dermal relaxant products. |
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V. PACKAGING & PRESENTATION |
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Sizes |
50 mg |
100 mg |
500 mg |
1 g |
A precision-engineered hexapeptide formulated for neurocosmetic performance and optimal skin delivery
Acetylated Hexapeptide sequence (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂)
Ultra-pure, pharmaceutical-grade peptide (≥99%)
Stable lyophilized form for formulation integrity
Compatible with aqueous and emulsion systems
Designed for high dermal bioavailability
Proven in vitro wrinkle reduction assays
Acetyl Hexapeptide-8 targets micro-tension at its source
relaxing facial contractions to deliver smoother skin look
Topical ranges: commonly 5–10% in consumer products
Clinical studies show visible wrinkle reduction in 7–15 days with consistent application.
Other studies indicate improved wrinkle appearance over 4–8 weeks in some formulations.
Yes, the peptide is well tolerated and non-irritating when used at recommended concentrations.
Yes. It complements collagen-stimulating actives when applied in separate or alternating formulations.
Next-Generation Life Science Products for Everyday Health.