Palmitoyl Tetrapeptide-7 is a lipophilic signal peptide that modulates cellular inflammatory responses and supports extracellular matrix renewal. It acts by downregulating pro-inflammatory cytokines such as IL-6 and IL-8, while simultaneously stimulating fibroblast activity and collagen synthesis. Through this dual action, it helps reduce dermal irritation, micro-inflammation, and photodamage — key factors in premature skin aging. Its lipid tail ensures excellent dermal penetration and stability, making it a cornerstone bioactive in anti-aging, repair, and post-procedure recovery formulations where restoring firmness and calmness is essential.
Peptide Type: Signal and anti-inflammatory peptide
Cat Number: PLS-SIG-008
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PRODUCT INFORMATION |
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Structural / Composition Data |
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Structure / Formula |
Palmitoyl Tetrapeptide-7 |
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Molecular Weight |
Pal-Gly-Gln-Pro-Arg |
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Appearance |
~802.0 Da |
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Purity |
White to off-white lyophilized powder |
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Solubility |
≥ 99% (HPLC) |
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Form(s) Available |
Soluble in water, glycerol, and ethanol (1:1) |
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Stability & Shelf Life |
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Storage |
Store at -20°C, or at 2–8°C (for 12 month), protected from light |
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Post-Reconstitution |
Stable for 7 days at 2–8°C |
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Stability Notes |
Stable for up to 24 months (lyophilized form) |
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Quality & Compliance |
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QC Tests |
HPLC purity, MS analysis, and peptide sequencing |
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Intended Use |
Cosmetic ingredient for anti-aging and skin-firming formulations |
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Documentation |
CoA, SDS, Specification Sheet, Technical Data Sheet |
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General Guidance |
Reconstitute with 1 mL sterile distilled water or buffer (pH 7.0–7.4), to obtain 100 mg/mL concentration. Gently mix until fully dissolved. Mix gently until completely dissolved. |
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Recommendations |
Avoid vigorous agitation or multiple freeze–thaw cycles. Add in final cooling stage of emulsions (<40°C). |
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Mechanism of Action |
Palmitoyl Tetrapeptide-7 reduces skin inflammation and photoaging by downregulating IL-6 and IL-8 cytokine production. It also stimulates new extracellular matrix (ECM) synthesis, enhancing collagen and hyaluronic acid levels to improve firmness and elasticity. |
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Biological Claims |
Reduces inflammatory responses, enhances skin barrier function, minimizes fine lines, and restores smooth texture. Synergistic with Palmitoyl Oligopeptides in complexes. |
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Intended Uses |
Anti-aging creams, repairing serums, wrinkle reduction formulas, post-laser care, eye contour products. |
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Sizes |
50 mg |
100 mg |
500 mg |
1 g |
An advanced biomimetic peptide designed for inflammation control and matrix rejuvenation
Palmitoyl Tetrapeptide-7 (Pal-GQPR) active sequence
Lipophilic tail for enhanced dermal penetration
Pharmaceutical-grade purity (≥99%)
Stable lyophilized formulation for long shelf life
Proven cytokine downregulation in vitro
Suitable for both emulsions and gel formulations
Palmitoyl Tetrapeptide-7 restores dermal balance by targeting the molecular sources of inflammation
It downregulates pro-inflammatory cytokines such as IL-6 and IL-8, helping prevent collagen breakdown and photoaging.
Preventing ECM breakdown and rebuilding collagen while preventing premature skin aging.
It inhibits IL-6 and IL-8 synthesis in fibroblasts, reducing inflammatory signaling and ECM degradation.
Yes, its anti-inflammatory mechanism makes it ideal for calming, sensitive, or post-procedure applications.
Commonly used at 0.5–2% depending on formulation type and desired efficacy.
Next-Generation Life Science Products for Everyday Health.